Each SARM Broken Down For You

How well do you know your research goal?

We are legally not allowed to advise you..

Just to clarify, this is not an advisory page (or website!).

We are a supplier. We are not big pharma, scientists, healthcare professionals or drug manufacturers.

We bring to market the purest pharma-grade SARMs, ensuring quality from raw material, to packaging, to your door. If we play by the rules, we can continue to do this for years to come.

There are many sources available for the information you are seeking but we are neither qualified nor allowed legally to advise on your research study.

We have however, broken down research links and given an overview of the role of SARMs.

Each SARM in production has specific functions it performs well, so SARM cycles or protocols should be tailored for specific goals and uses.

An ideal SARM (selective androgen receptor modulator) is an “orally active agent with once daily dosing and anabolic effects on muscle and bone, but no or lesser activity in the prostate,” according to Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium, a seminal SARM research paper published by current president and CSO at TransMed Institute Andres Negro-Vilar.

What we can tell you..

Sales trend analysis we have done suggests most researchers choose one primary anabolic (muscle building) compound, such as RAD-140 or LGD-4033or S-23 or S-4More is not always better.

If and when a study involves multiple goals (such as also injury recovery/prevention, losing fat, increasing endurance, reducing myostatin, increasing GH, or lowering estrogen levels), we generally see a primary SARM stacked with one or more secondary compounds (such as, respectively, MK-2866, or GW-501516 and/or SR-9009, or YK-11, or MK-6777 to achieve these goals.

Today there are many SARMs in various stages of testing, as well as SARMs that have been side-stepped due to less than positive findings, side-effects or lack of biological efficiency or scientific efficacy. The main draw of SARMs is that they reportedly have many of the beneficial (anabolic) effects of AAS (anabolic-androgen steroids), minus the harmful, androgenic, or undesired side-effects. However, each type of SARM interacts different biologically, has different experimental and medical use cases, and different ratios of anabolic to androgenic effects — with some showing noticeable adverse effects when used at high doses.

REMEMBER

SARMs are not approved for human consumption

MK-2866 (Enobosarm, Ostarine, GTx-024, S-22) Overview

Strength:3.5/5 Endurance:3/5  Fatloss:3/5  Size:3.5/5

Very common, very versatile SARM. Moderate, consistent effects on muscle and strength gains; cited as "injury prevention or recovery" SARM due to focused AR binding to bone and surrounding tissues.

Developed for the treatment of conditions such as muscle wasting and osteoporosis by GTx Incorporated, a pharmaceutical company headquartered in Memphis, Tennessee, the use of MK-2866 by professional athletes in training sparked the 2008 ban of SARMs by WADA, the World Anti-Doping Agency. Since then, the United States Anti-Doping Agency has published a detailed profile of MK-2866, stating that the number of athletes who have tested positive for MK-2866 had increased steadily over the past few years. Because of its ubiquitous use in athletics, Ostarine is the SARM that often makes headlines.

This SARM is less potent than aforementioned LGD4033, and is commonly used in experiments involving maintaining muscle, rather than building muscle mass. Notwithstanding the much lesser anabolic effects, MK2866 has a similar profile otherwise, with side effects well-tolerated. As with Ligandrol use, no aromatisation is observed, thus recipients are not prone to estrogen-related side effects such as Gynecomastia (“gyno”).

MK-2866 has been shown to increase the rate of collagen synthesis and (re)build tendons, thus its use in injury prevention and repair is ideal. Interestingly, significant increases in bone density are also universally observed in recipients, making Ostarine a powerful weapon in the fight against osteoporosis.

To determine the effects of MK-2866 on muscle wasting and physical function, researchers enrolled male and female patients with cancer who had at least 2 percent weight loss in the previous 6 months. Patients received once-daily oral MK-2866 1 mg, 3 mg, or placebo for up to 113 days, and change in total lean body mass from baseline was measured at the end of the study. “Compared with baseline, significant increases in total lean body mass by day 113 or end of the study were noted in both MK-2866 groups,” the researchers concluded. No serious side-effects were recorded.

MK-2866 (Ostarine) Chemical Profile:

https://en.wikipedia.org/wiki/Enobosarm

MK-2866 Side Effects

Very few reports of adverse side-effects.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

RAD-140 (Testolone) Overview

Strength:4/5 Endurance:2/5  Fatloss:1.5/5  Size:5/5

The newest popular SARM and the most powerful in terms of anabolic activity, RAD140 has recently made waves in the medical community because its developer, Radius Health, announced that the first patient had been enrolled in the company’s Phase 1 study of the SARM.

Along with the promising potential use of RAD140 in hormone receptor-positive breast cancer, this SARM is perhaps known best for muscle-mass-enhancement, due to its very high ratio of anabolic to androgenic effects, which are estimated at 90:1, the highest ratio of all SARMs. No wonder then that the muscle-building effects of RAD140 rival even some AAS, but without the high androgenic side effects associated with the use of traditional steroids. When used for building muscle, doses typically range from 4 mg a day to 12 mg a day, and most RAD140 experiments end in 6 weeks, followed by 3 weeks of mild PCT.

RAD-140 (Testalone) Chemical Profile:

RAD-140 Side Effects

Testosterone suppression with prolonged use; few reports of other adverse side-effects.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

RAD-140 Commonly Stacked With View all

LGD-4033 Overview

Strength:4/5  Endurance:2/5  Fatloss:1.5/5  Size:4.5/5

LGD-4033, also known as Ligandrol or VK-5211, is perhaps the most common SARM, and one of the most thoroughly researched SARMs currently available. First discovered and patented by Ligand Pharmaceuticals and currently developed by Viking Therapeutics, LGD-4033 shows a lot of potential for treatment of conditions such as muscle wasting and osteoporosis.

LGD4033 has exhibited low side effects in studies, yet it is one of the most potent anabolic SARMs. Test subjects consistently yield strong gains in muscle mass, but fat reduction is not a primary effect of this compound. Ligandrol does not aromatize to cause increases in estrogen levels. It is moderately suppressive to the body’s production natural of testosterone, however this effect is short-lived once daily dosage is stopped.

One placebo-controlled SARM study tested the effects of 0.1, 0.3, or 1.0 mg of LGD-4033 daily for 21 days on 76 healthy men between 21 and 50 years to determine how it affects blood counts, chemistries, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength. The researchers concluded that LGD-4033 is safe, and is capable of increasing lean body mass without a change in the prostate-specific antigen.

Even at 1 mg, LGD-4033 leads to dose-dependent suppression of total testosterone, sex hormone-binding globulin, high-density lipoprotein cholesterol, and triglyceride levels. However, hormone levels and lipids return to baseline after the discontinuation of LGD-4033 administration.

When used for its strength and muscle building effects, the average dose is around 5 mg a day, with recommended dosages at 10-20 mg a day, and maximum dose regarded to be 30 mg a day.

LGD-4033 (Ligandrol) Chemical Profile:

https://en.wikipedia.org/wiki/Ligandrol

LGD-4033 Side Effects

Testosterone suppression with prolonged use; few reports of other adverse side-effects.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

LGD 4033 Commonly Stacked WIth View all

SR-9009 (Stenabolic) Overview

Strength:2.5/5 Endurance:4.5/5 Fatloss:4/5 Size:2/5

While not technically a SARM, Stenabolic is often classified as such due to it’s clinical outcomes, including enhanced muscle growth and fat oxidization. SR-9009 was first developed in 2013 by Scripps Research (hence ‘SR’) Institute as an agonist (enhancer) of Rev-ErbA, the proteins that stabilize the internal clock in mammals.

Although SR-9009 was created to study and assist our circadium (sleep) rhythm, other study outcomes included reduction in anxiety, and increases in muscle growth and endurance. Mechanisms responsible for this increased exercise capacity are increased oxygen consumption and increased mitochondria counts in skeletal muscle.

Further benefits included decreases cholesterol, weight, and inflammation in studies in mice, as the REV-ERB proteins
decrease triglyceride production and turn off genes responsible for fat storage.

SR-9009 (Stenabolic) Chemical Profile

SR-9009 Side Effects

Very few anecdotal reports of adverse side-effects.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

SR-9009 Commonly Stacked With View all

GW-501516 (Cardarine) Overview

Strength:2/5 Endurance:4.5/5 Fatloss:4/5 Size:2.5/5

Known as the "endurance SARM" and fat loss associated with going further and longer on same calories; slight anabolic activity for some; similar to SR-9009 but longer half-life so more flexible administration.

GW-501516 has been linked in studies to dramatic improvements in metabolism, endurance and general physical performance. Maker GSK completed two phase II clinical studies relating to reduction in obesity, diabetes and cardiovascular disease, but discontinued development of Cardarine when animal testing revealed its propensity for carcinogenic risk.

Health benefits purported by Cardarine researchers include improved immune system support, brain and heart health & protection, and mild muscle growth. Cardarine, however, is most often associated with increases in metabolism, stamina and endurance, qualities sought after by runners and cyclists, since its binds to and activates PPAR delta (peroxisome proliferator activator receptors), and AMPK and PPAδ agonists are exercise mimetics (source).

Reported dosages range from 5-10mg daily.

GW-501516 (Cardarine) Chemical Profile:

GW-501516 Side Effects

Very few reported; one study in rats showed ultra-high doses could cause cancer.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

MK-677 (Ibutamoren) Overview

Strength:4/5 Endurance:3/5  Fatloss:4/5  Size:4.5/5

Often ran concurrently with any SARM or Prohormone - MK677 is as anabolic as the stack it is used with.

MK677 is produced by Reverse Pharmacology, which markets the drug as Nutrobal, designed to stimulate the pituitary gland to release growth hormone. MK677 is an orally-active growth hormone secretagogue, thus it mimics human growth hormone (HGH)-stimulating action of the hormone ghrelin (source). This SARM behaves like oral-HGH, stimulating GH/insulin-like growth factor-I. It has a longer-than-usual half life of 24 hours, and is often administered in long-term experiments.

Ibutamoren was originally designed to mitigate obesity, muscle wasting, and osteoporosis (source). In testing, Ibutamoren boosts IGF-1 serum concentration and plasma growth hormone (GH) levels in both humans and animals, and stimulates body weight changes such as increases in lean body mass. Side-effects include increase in hunger and, potentially, increases in cortisol levels. Increased insulin resistance is noted within 6 weeks, with significant body fat decreases after 26 weeks.

Like MK-2866, the MK-677 SARM is often used within athletics and
bodybuilding as a performance-enhancer, despite warnings from the FDA and WADA. Typical study dosing is observed at
10mg-15mg daily. Ancillary benefits often attributed to MK677 include healing
of ligaments, tendons, bones, and injuries, gains in size and lean muscle mass,
improvements in skin tone and elasticity, and increases in oxidation and higher
utilization of fat stores.

MK-677 (Ibutamoren) Chemical Profile:

MK-677 Side Effects

Some complain of lethargy, increased appetite, tingly or numb hands/fingers.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

S-4 (Andarine) Overview

Strength:3/5 Endurance:2/5 Fatloss:2/5 Size:3.5/5

A tried-and-true anabolic; moderate metabolic enhancements; effects often cited as a dry, hard, lean, etc.

Commonly known as Andarine, S-4 is developed by GTx Incorporated for the treatment of conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy. While less potent than other SARMs, with lower anabolic and androgenic effects, relatively low doses of S-4 have been found to build muscle mass in rodents, demonstrating tissue-selective pharmacological activity.

A recent study has studied the metabolite of S-4 in plasma by administering the compound to in equine testing. The study found administration of S-4 leads to three major metabolic reactions: amide hydrolysis, hydroxylation, and sulfonation, and products of these metabolic reactions could be detected for 12 hours. These insights help researchers determine appropriate targets for doping control as S-4 becomes increasingly popular as a performance-enhancing drug because of its ability to increase muscle and bone mass without affecting the prostate.

S-4 is often taken in doses of up to 50 mg a day for 4 to 8
weeks. Doses exceeding 50 mg have been anecdotally confirmed to cause temporary vision problems, such as a yellow tint in vision. These side-effects are known to subside soon after discontinuation of usage.

S-4 (Andarine) Chemical Profile:

S-4 Side Effects

Some complain of lethargy, increased appetite, tingly or numb hands/fingers.

Source: UGC. Individual research goals and outcomes vary. This is user-generated content. As such, it is anecdotal and non-scientific.

S-4 is Commonly Stacked With View all

S-23 Overview

Strength:4/5 Endurance:3/5 Fatloss:3/5 Size:5/5

S23 was created by altering the chemical structure of a compound named C-6. S23 is actually an improved version of C-6, showing higher bioavailability and higher binding affinity.

S23 boasts very high bioavailability, up to 96% and shows one of the highest binding affinities among all the SARMs out there, comparable to LGD-4033. S23 is a full agonist of the androgen receptor and is the only SARM, alongside LGD-4033 to have that honor.

Naturally, this makes S23 very suppressive and comparable to steroids when it comes to the Testosterone suppression experienced.

S23 mainly mimics testosterone and stimulates the growth of bone tissues and muscle cells in the body. It mostly achieves this by only binding with the androgen receptors in your body. 

S23 also suppresses the two main hormones that make sperm - LH (Luteinising Hormone) and FSH (Follicle-Stimulating Hormone). Therefore, it is slowly being tested and developed as a drug that can potentially be used as a male contraceptive. 

According to several lab tests, the S23 half-life is about 11.9 hours. Most of it is absorbed within the first four hours. It is within this duration that the compound achieves its highest lean muscle mass building and contraceptive qualities. 

The compound has numerous reported benefits, and the only reason it is still under controversy is that it has not been entirely tested yet. 

It is being researched by a pharmaceutical company by the name of GTX that specialises in hormonal drugs. 

S-23 Chemical Profile